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Apixaban vs. warfar...
Apixaban vs. warfarin with concomitant aspirin in patients with atrial fibrillation : insights from the ARISTOTLE trial
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Alexander, John H. (author)
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Lopes, Renato D. (author)
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Thomas, Laine (author)
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Alings, Marco (author)
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Atar, Dan (author)
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Aylward, Philip (author)
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Goto, Shinya (author)
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Hanna, Michael (author)
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Huber, Kurt (author)
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Husted, Steen (author)
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Lewis, Basil S. (author)
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McMurray, John J. V. (author)
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Pais, Prem (author)
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Pouleur, Hubert (author)
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Steg, Philippe Gabriel (author)
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Verheugt, Freek W. A. (author)
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Wojdyla, Daniel M. (author)
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Granger, Christopher B. (author)
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- Wallentin, Lars (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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(creator_code:org_t)
- 2013-10-20
- 2014
- English.
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In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 35:4, s. 224-232
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Aims We assessed the effect of concomitant aspirin use on the efficacy and safety of apixaban compared with warfarin in patients with atrial fibrillation (AF). Methods and results In ARISTOTLE, 18 201 patients were randomized to apixaban 5 mg twice daily or warfarin. Concomitant aspirin use was left to the discretion of the treating physician. In this predefined analysis, simple and marginal structured models were used to adjust for baseline and time-dependent confounders associated with aspirin use. Outcome measures included stroke or systemic embolism, ischaemic stroke, myocardial infarction, mortality, major bleeding, haemorrhagic stroke, major or clinically relevant non-major bleeding, and any bleeding. On Day 1, 4434 (24%) patients were taking aspirin. Irrespective of concomitant aspirin use, apixaban reduced stroke or systemic embolism [with aspirin: apixaban 1.12% vs. warfarin 1.91, hazard ratio (HR) 0.58, 95% confidence interval (CI) 0.39-0.85 vs. without aspirin: apixaban 1.11% vs. warfarin 1.32%, HR 0.84, 95% CI 0.66-1.07; P interaction = 0.10] and caused less major bleeding than warfarin (with aspirin: apixaban 3.10 vs. warfarin 3.92%, HR 0.77, 95% CI 0.60-0.99 vs. without aspirin: apixaban 1.82% vs. warfarin 2.78, HR without aspirin 0.65, 95% CI 0.55-0.78; P interaction = 0.29). Similar results were seen in the subgroups of patients with and without arterial vascular disease. Conclusion Apixaban had similar beneficial effects on stroke or systemic embolism and major bleeding compared with warfarin, irrespective of concomitant aspirin use.
Keyword
- Concomitant medications
- Aspirin
- Atrial fibrillation
- Stroke
- Systemic embolism
- Major bleeding
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Alexander, John ...
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Lopes, Renato D.
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Thomas, Laine
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Alings, Marco
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Atar, Dan
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Aylward, Philip
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show more...
-
Goto, Shinya
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Hanna, Michael
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Huber, Kurt
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Husted, Steen
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Lewis, Basil S.
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McMurray, John J ...
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Pais, Prem
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Pouleur, Hubert
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Steg, Philippe G ...
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Verheugt, Freek ...
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Wojdyla, Daniel ...
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Granger, Christo ...
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Wallentin, Lars
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show less...
- Articles in the publication
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European Heart J ...
- By the university
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Uppsala University